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Next-Generation Sequencing COVID-19 Sample Submission
Sending positive samples to the Infectious Disease Laboratory
October 2025 Update:
The Minnesota Public Health Lab’s Infectious Disease Lab (IDL) has been requesting that a proportion of specimens positive for SARS-CoV-2 be submitted for next generation sequencing (NGS) to better understand the emergence and trends of variants circulating in the community.
All laboratories (regardless of size): submit up to 40 positive specimens per week.
Note: MDH-PHL is no longer asking specifically for specimens from vaccine breakthrough cases or suspected re-infection. Those specimens can be submitted as part of the weekly submission for surveillance.
The Minnesota Department of Health (MDH) CloudDrive application is a secure file drop location for standard batch submission spreadsheets. It was designed to make large submissions of 25 or more specimens less time-consuming.
Once your facility is approved, MDH will send you directions for logging into your account and the spreadsheet template for data submission. Files dropped into the CloudDrive will be accessible for 90 days.
CloudDrive login and upload directions (PDF)
If you are interested in using the CloudDrive to submit spreadsheets of 25 specimens or more for sequencing submission, please fill out the CloudDrive Submission Interest Form.
Patient test reports will not be generated for sequencing tests. Minnesota-focused subsampling data is available at MDH Variants Dashboard at Case and Variant Data.
Variant tracking and results reporting: While the Minnesota Department of Health is working internally to provide regular variant updates to the general public, the high-level Minnesota variant report will be shared with submitters via MLS on a bi-weekly basis.
Please Contact the Infectious Disease Laboratory with any questions.